‘Sure, that may be about correct. I seek for a physical comprehension of Organic techniques in a very base-up way. I think you could possibly distinguish a few lines of investigation in my team in the meanwhile. The main issues chromosome construction: How does one get a metre-extended DNA polymer folded and organised in this type of microscopic mobile? We've produced visualisation approaches that allow for us to study how, as an example, SMC proteins loop DNA (movie on Youtube) so as to build up chromosomes.

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Nanofabrication of electrodes with sub-5 nm spacing for transportation experiments on single molecules and steel clusters

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Experimental period diagram of negatively supercoiled DNA measured by magnetic tweezers and fluorescence,

What distinguishes biology from chemistry is usually that these elements together make up a residing method. The trick of stated everyday living, I believe, lies in the interactions, the interplay of Those people molecules. https://www.ceesdekker.net The large dilemma in regards to the origin of life continues to be unanswered. How did we at any time evolve from easy molecules in the very advanced systems we see nowadays? We do not know. I want to operate on These types of large, open up questions.’

Nanopores characterize a sublime and multipurpose Resource to evaluate one molecules. We investigate novel detection modes with good-point out nanopores together with several solutions to evaluate proteins with nanopores. Assignments encompass the next:

The rotors harness Strength from a nanoscale drinking water and ion movement that is created by a static chemical or electrochemical prospective gradient within the nanopore, which happen to be founded by way of a salt gradient or applied voltage, respectively. These synthetic nanoengines self-organize and run autonomously in physiological situations, suggesting ways to developing Power-transducing motors at nanoscale interfaces.

Resolving the step size in condensin-driven DNA loop extrusion identifies ATP binding given that the move-building system

FtsZ treadmilling is essential for Z-ring condensation and septal constriction initiation in bacterial cell division

Later on we spoke all over again briefly simply because Dekker felt that our discussion of his faith speedily turned purely philosophical, Whilst it also concretely aids him in his operate.

Permit’s 1st glimpse again for the time being once you chose to shift your target from superconductivity and nanotubes to biology at the end of the 1990s.

The biophysicist from Delft – who has actually been Among the most cited researchers inside the Netherlands For many years – takes his obligation to lead for the explanation and popularisation of his do the job for the border of physics and biology really critically and regularly seems inside the media; if not to look at his perform, then about the relationship involving science and his Christian faith.